Investigation of plasma and tissue Ghrelin and Obestatin levels in histopatologically diagnosed uterine leiomyoma and endometrial polyp

Investıgatıon Of Plasma And Tıssue Ghrelın And Obestatın Levels In Hıstopatologıcally Dıagnosed Uterıne Leıomyoma And Endometrıal PolypMyoma uteri is a common benign tumour of the uterus. Endometrial polyps are local epithelial cooted growths that are originating from endometrial tissue and containing different amount of gland, stroma and blood vessels.We designed this study to determine the appearence of ghrelin, GHS-R, ghrelin protein m-RNA in endometrium & myometrium and the tissue around endometrium and myometrium. Also we examine the levels of these peptids in the serum of polyp and myometrium groups and wanted to investigate the role of these peptides in the pathophysiology of polyps and myomas.This study is due on 45 patients with leiomyom and 15 patients with endometrial polyp. Normal myometrium and endometrium are used for the control group Tissues in all groups are dyed by anti-ghrelin and anti-obestatin anticores. Also the tissue and serum of all cases are examined by enzyme immunoassay (EIA) and ELISA methods. The levels of acil ghrelin, desacil ghrelin, total ghrelin and obestatin are examined between groups and correlation between immunohystochemical dye is made.As a result we here in demostrated fort the first time that ghrelin and obestatin are expressed in both endometrial polyp and uterin leiomyoma. More clinical stıdies are needed to highlihght the role of these to hormones in the etiopathogenes of endometrial polyp & uterin myomas.Keywords; Uterin leiomyoma, endometrial polyp, ghrelin, obestatin