Comparison of intralesionary concantrated growth factor (CGF) application to chronic ulcer wounds and conventional dressing methods

Purpose: In our study, we aimed to investigate the effect of concentrated growth factor (CGF) application on conventional dressing therapy and treatment course in the treatment of diabetic ulcers. Method: Patients with chronic ulcerated wounds who were followed up in the Chronic Wound Care Unit of the Department of Orthopedics and Traumatology of Pamukkale University Hospitals were divided into CGF (n=24) and wet dressing (n=23) groups and wound site treatment was planned. In the CGF application, IV blood samples taken from patients were applied to patients with a concentrated gel obtained by centrifuging (Elektromag M815A) in non-anticoagulant tubes. In the wet dressing group, the wound site was debrided and covered with wet gauze and no additional procedures were applied. The patients in the study underwent 12 procedures and their results were recorded and analyzed. Results: 16 patients (34%) were women and 31 patients (66%) were men in the study. The patients included in the study were between 27 and 85 years old and had an average age of 63.23 years. While Group 1 received treatment for an average of 32.78 days, treatment continued for 35.13 days in Group 2 (p=0.218). While an average of 10.22 procedures were performed in Group 1, an average of 11.04 procedures were performed in Group 2, and there was no statistically significant difference (p=0.566). The wound perimeter value was 364.28 average in Group 1 as a result of the last procedure, while it was 755.66 average in Group 2 (p=0.033). There was no statistically significant difference between the mean of the procedure and the first procedure in the wound area, wound perimeter and wound length scores between the groups (p>0.050). However, there was a significant difference between the groups in the last procedure wound area and wound perimeter scores(p=0,031/p=0,033). There was a significant in-group difference between the firdt procedure score and the last procedure score for Group 1 in the wound area score, the wound perimeter score, and the wound length score (p=0.0001). The wound area score, the wound perimeter score, and the wound length score were similarly 4-10th procedures. It was observed that there was a pause period between procedures. Enterobacter Cloacae was the most common microorganism with 8 patients in Group 1, Enterococcus Faecalis and Methicillin Susceptible Staphylococcus Aureus were the most common microorganisms in Group 2 with 6 patients each. Conclusions: Wound area, perimeter and length of patients significant improvement was observed in the treatment with concentrated growth factor (CGF) until the 4th procedure. We saw that the recovery paused between 4-10 treatments. We observed that the recovery accelerated again from the 10th procedure. We think that the use of CGF in diabetic foot ulcer accelerates wound healing and is a cost-effective treatment option that can be used safely as a treatment method.