Relations of clinical parameters and effects on prognosis of genomic polymorphisms in XPD, XRCC1 and XRCC4 in patients with multiple myeloma

In this study, relations of clinic parameters and effects on prognosis of genomic polymorphisms in XRCC1-399, XPD-751, XRCC4 intron3 and XRCC4-1394 are assessed in patients with multiple myeloma. Sixty patients with multiple myeloma in Haemotology department in Internal Medicine of Gaziantep University hospital are included. Healty 70 people without any heamotological malignancies are icluded as control group. Distribution of XRCC1 codon 399 gene polymorpism is AA: 25(39.7%), AG: 20(33.3%), GG: 17(28.3%), distribution of XPD codon 751 gene polymorpism is AA: 27(%42.8), AC: 25(%39.7), CC: 11(%17.5), distribution of XRCC4intron3 gene polymorpism is DD: 1(1.6%), DI: 38(60.3%), II: 24(38.1%) and distribution of XRCC4-1394 gene polymorphism is TT:14(%22.2), TG:29(%46.0), GG:20(%31.2). No significant relation is found between XRCC1-399 and XPD-751 gen polymorphisms and MM. D allel (p=0.03) ve DD genotype (p=0.007) in XRCC4 intron3 gene polymorphism and TT genotype (p=0.04) in XRCC4-1394 gene are significantly decreased in patients with MM in comparison with control group.As a result, there cannot be any relation between XRCC1-399 and XPD-751 gen polymorphisms and MM, however, decreases in D allel and DD genotype in XRCC4 intron3 and decreases in TT genotype in XRCC4-1394 gene thougt as increasing the tendency in multiple myeloma.Key words: Multiple myeloma, XRCC1, XPD, XRCC4