Investigation of the effect of multiple sclerosis on peripheral nervous system

Multiple sclerosis is an autoimmune central nervous system disease characterized by inflammation, demyelination and axon damage. There are three subtypes of multiple sclerosis with different clinics.: relapsing remitting, secondary progressive and primary progressive. The aim of this study was to determine peripheral nerve involvement and related factors in patients with multiple sclerosis. In our study, 35 (70.0%) of the patients were Relapsing Remitting Multiple Sclerosis and 15 (30.0%) with Secondary Progressive Multiple Sclerosis. The mean age of the symptom onset of the patients was 30.44 ± 1.06 years, the mean score of the Multiple Sclerosis Disability Scale (EDDS) was 2.97 ± 2.58 points and polyneuropatia was detected in 12 (24.0%) patients. Polyneuropathy was detected in 3 patients (6.0%) in the control group. In our study, peripheral nerve involvement was higher in male patients than female patients. There was a very strong positive correlation between the duration of disease development and the Extended Multiple Sclerosis Disability Scale scores. In the study, it was determined that patients with multiple sclerosis were more seen in women in accordance with the literature, EDDS scores increased as the disease duration increased, and the frequency of polyneuropathy in men was higher than in women. In addition, the frequency of polyneuropathy in the control group was higher than expected.