Evaluation of fasting and postprandial plasma GLP-1 concentrations in childhood obesity

This study was designed to find out whether there is any difference inthe concentrations fasting and postprandial plasma GLP-1 in obesity and normalweight children.Material and Method: The study population consisted of 40 obesity and 15healthy control children. Whose age, sex, height, weight, BMI, and pubertalstatus are matched. Immediately after sampling for blood glucose,insülin and GLP-1. The subjects were administered a standard oral glucose tolerance test. Another sampling was performed for plasma glucose,insülin and GLP-1 levels at 60-120 minutes.Results: Body mass index were different in obesity anf healthy control groupChildren. As expected blood glucose and plasma GLP-1 levels both pre and60,120 min after OGTT; were different between groups. Plazma GLP-1 levels were not correlated with endogenous insülin secretion, in either group.Conclusions: The concentrations fasting and postprandial plasma GLP-1 reducedin obesity after OGTT. This decreased levels of GLP-1 study results suggest a role for GLP-1 in the obesity pathogenesis and tendancy for diabetes.