The study of genetic polymorphism, of inflammatory molecules in patients WHO have the risk of periodontitis and peri-implantitis

As observed in many diseases, genetic predisposition factors also affect the progress of periodontitis and peri-implantitis. This study examines if there is any solid genetic predisposition causing periodontitis and peri-implantitis formation in Turkish patients. In order to evaluate single nucleotide polymorphism (SNP), IL-8 and fMLP, playing a role in the chemotaxis of neutrophils, and FcγRIIA and FcγRIIIA receptors, playing a role in the antigen-antibody complexes and phagocytosis, were selected. Thirty-two Turkish non-smoking patients with periodontitis, thirty-three Turkish non-smoking patients with peri-implantitis and thirty-three Turkish non-smoking healthy patients were selected. In total 98 adults participated in our study. Collected saliva samples from the participants were used for DNA isolation. SNPs were determined in these subgroups of the study by means of genotype-specific polymerase chain reactions. When IL-8 A-251T, FcγRIIa -H131 and FcγRIIIa -V158 polymorphism were evaluated, no significant difference was found between periodontitis, peri-implantitis and healthy groups. However, this study observed that fMLP Receptor (FPR1) gene polymorphism creates a significant difference in individuals at higher risk of periodontitis or peri-implantitis. Statistical analyses show that individuals with the G genotype have a higher risk of periodontitis, while individuals with G / C genotype have higher risk of peri-implantitis.