Comparison of serum levels of cell adhesion molecules (eselectin, -selectin, İCAM-1, VCAM-1, LRG-1) in placentaladministration and adhesion anomalies with patients with vaginal delivery and former cesarerean

Objective: The effect of cell adhesion molecules on placental location and adhesion anomalies was investigated. Materials and Methods: Patients between March 2020 and September 2021 were included in the study. While 56 patients aged 18-50 years, out of 153 cases formed the placental adhesion and/or localization anomaly group, 55 cases without placental adhesion anomaly (placental invasion anomaly and/or previa pathology) constituted the cesarean section group and 42 cases constituted the vaginal birth control group. Demographic characteristics and histories of 153 patients were questioned. I-CAM-1, V-CAM-1, E-Selectin, P-Selectin, LRG-1 levels were studied. Results: There were significant differences in E-Selectin, P-Selectin, ICAM-1 and LRG-1 values between the groups (p<0.05). There was a significant difference between the NVD and PP groups in terms of E-Selectin (p=0.038). In terms of P-Selectin, there was a significant difference between the C/S and PP groups (p=001). P-Selectin was higher in the PP group. There was a significant difference between the NVD, C/S group (p=0.041) and the NVD, PP group (p=0.013) in terms of ICAM-1, but there was no significant difference between the C/S and PP groups. In terms of LRG-1, there was a significant difference between all 3 groups (p<0.05). Conclusions: Although the underlying mechanism of placental invasion anomalies is still unclear, it has been shown that it may be related to a histopathological mechanism associated with chronic inflammation, low maternal vascular blood flow and hemorrhage. Therefore, it is thought that some inflammation, invasion and adhesion molecules may play a role in this process. In our study, all adhesion molecules except V-CAM-1 were found to be significantly higher in the PP group. E-Selectin and LRG-1 adhesion molecules were found to be significantly higher even in C/S patients compared to normal delivery. As a result; these adhesion molecules can be studied as a marker in PP patients. Key Words: Placenta previa, Placenta accreata, E-Selectin, P-Selectin, ICAM-1, VCAM-1,LRG-1