To evaluate the distribution of follicles in the ovaries of women with polycystic ovary syndrome ultrasonographically and to detect the granulosa cellphysiology of ovaries with peripheral follicular coniiguration and multifollicular configuration by meansof AMH

OBJECTİVE: The aim of this study; to evaluate the distribution of follicles in the ovaries of women with polycystic ovary syndrome ultrasonographically and to detect the different granulosa cell physiology of ovaries with peripheral follicular configuraiton and multifollicular configuraiton by means of AMH. METHOD: It is a prospective cross-sectional study. The cases were selected among the patients who applied to the general gynecology and PCOS outpatient clinics of Bursa Uludağ University, Department of Obstetrics and Gynecology between February 2019 and October 2020. The patients were divided into two groups: the PCOS group (PCOP) with a peripheral configuration ultrasonographically and the PCOS group (MF) with a multifollicular configuration ultrasonographically. A total of 273 cases were included in the study, 226 cases in the PCOP group and 47 cases in the MF group. Serum FSH, LH and Estradiol levels were studied on the 3rd day of the cycle and serum progesterone levels were studied on the 21st day of the cycle. Independent of the cycle day; AMH, PRL, Total Testosterone, Free Testosterone, 17-OH-PRG, Androstenedione, HbA1c and TSH, PRL and fasting blood glucose were studied. Age, AFC, BMI, ovarian volumes and mFG scores were recorded. Statistical analyzes were performed using the IBM SPSS 23.0 program. RESULT(S): When the AMH levels of the two groups included in the study were compared, a significant difference was found between them (p=0.06). There was a significant difference in age, total testosterone, free testosterone, DHEAS and 17-OH-PRG, 21st day progesterone, fasting blood sugar values and ovarian volumes of both groups (p<0.001 / p=0.006 / p=0.013 / p). =0.003 / p=0.001 / p=0.006 / p=.000 / p=.000). CONCLUSION(S): In this study, it was aimed to ultrasonographically evaluate women with a diagnosis of Polycystic Ovary Syndrome and to determine the granulosa cell physiology of ovaries with peripheral follicular configuration and multifollicular configuration by means of AMH, and a significant relationship was determined according to the data obtained. Age value was significantly lower in the PCOP morphology group than in the MF morphology group. Since the primary objective of the study was to evaluate the granulosa cell physiology of the ovaries in PCOP morphology and MF morphology, the resulting result creates confusion as to whether the current significant difference is due to physiological difference or age gain. There is still a lot of information to be gained to fully understand the pathophysiological role played by granulosa cells and thus AMH in PCOS.