Effects of life style modifications on echocardiographic and biochemical parameters in prehypertensive patients

Introduction: Recent studies show that the prevalence of prehypertension as a predictive of hypertension is common in both our country and worldwide and will increase.Purpose: We aimed to determine the effects of DASH diet and exercise treatment on clinical, biochemical and echocardiografic parameters in prehypertensive patientsMethods: Subjects were 20 to 40 years old and had blood pressure of 120 to 139 mmHg / 80 to 89 mmHg and < 120/80 mmHg. They were treated with DASH diet and exercise during 6 months. After treatment we evaluated the clinical, biochemical and echocardiografic parameters in prehypertensive and normotensive groups.Results: It has been showen that the basal weight, GFR, OGTT and homocysteine in prehypertensive group were different from normotensive group. The responsive of blood pressure insulin, insulin resistance, GFR and homocysteine to DASH diet and exercise were beter in the prehypertensive group when compared to normotensive group. In our study there were 6 patients with diastolic dysfunction in prehypertensive group and no patients with diastolic dysfunction were found in normotensive group. After treatment 4 patient with diastolic dysfunction showed improvement.Conclusions: Significant improvement in blood pressure, insulin, insulin resistance and homocysteine were found with DASH diet and exrecise in prehypertensive group when compared to normotensive group.Further study with large number of participants are needed to determine effects of DASH diet and exercise on diastolic dysfunction in prehypertensive patients.Key Words: prehypertension, diastolic dysfunction, life style modifications