Synthesis, characterization and applications of kopolymers kontaining poly (N-izopropilakrilamid) loaded progesterone

In this thesis study; poly(N-isopropylacrylamide) (PNIPAM) containing vegetable oil based polyN-isopropylacrylamide-co-polymethacryloyl linseed oil (PNIPAM-co-PMLO) and Poly N-isopropylacrylamide-co-polymethacryloyl soybean oil (PNIPAM-co-PMSO) and PNIPAM polymeric gels were prepared using polymethacryloyl linseed oil (PMLO) or polymethacryloyl linseed oil (PMSO) comonomers, N-isopropylacrylamide (NIPAM) monomer, methylene bisacrylamide as crosslinker, ammoniumpersulfate-TEMED redox couple as initiator by free radical polymerization the method. It was carried out at room temperature of hydrogels synthesis and under 0 oC of cryogels synthesis. Characterization of the obtained polymeric gels were investigated at tructure analysis with FTIR-ATR, thermal analysis with DSC and TGA methods and morphological structures with scanning electron microscope (SEM-EDX). The swelling ratios of polymeric gels were calculated at 25 oC and 37 oC temperatures. It was observed that swelling rates decreased with temperature rise in the water. Moreover, Progesterone loading-release for polymeric gels studies were performed in-vitro medium at 25 oC and 37 oC. The progesteron loading rates of the polymeric gels were found to be approximately over 91-% at the end of second hour.and over 85-% at the end of 24 hours. Progesterone release studies were found to be around 55% at the end of 24 hours. Release studies of Progesterone loaded PMLO -co-PNIPAM gels at 25°C were found about 58-% for cryogel and 65-% for hydrogel. at the end of 24 hours. However progesterone release values in polymeric gels were increased at 37 C. The obtained results were compared with the release values of 2 different progesterone-loaded implants used in veterinary medicine. Keywords: Poly(N-isopropylacrylamide), Vegetable Oil, Hydrogel, Cryogel, Progesterone, Controlled Drug Release.