Pterjiyumda ACTR2 gen ekspresyonu

Pterygium is a benign, uncontrolled growth of conjunctival tissue extending over the sclera. Pterygium is characterized by inflammatory, proliferative, invasive ocular surface and extensive matrix remodeling. Pterygium is a benign growth of conjunctival tissue lining the sclera that is proliferative and causes invasive ocular surface and extensive matrix remodeling. the ACTR2 gene is located on the p arm (short arm) of autosomes (body chromosome(s)) at locations 2p14 encoding the 399 amino acid sequence. The ACTR2 gene consists of 10 exons and consists of 3798 base pairs. ACTR2 encodes Actin-Associated Protein 2 (ARP2), is involved in the formation of branched actin networks in the cytoplasm, important for cell shape. It provides force for cell motility and takes part in cell proliferation. loss of ACTR2 or the presence of abnormal transcripts can result in aberrant cellular proliferation by the activity of ACTR2. In this study, it was aimed to determine the ACTR2 gene expression, which may cause abnormal benign tissue growth from the conjunctiva (mucous membrane covering the eye) to the cornea. It depends on cell adhesion, motility, and deformability resulting from quantitative changes and rearrangement of the actin-related protein. Our aim in this study is to determine the expression level of ACTR2 gene in pterygium tissue. qRT-PCR analysis was performed for expression of ACTR2 gene at RNA level in pterygium tissue. According to the data obtained at the end of the study, ACTR2 gene expression levels were found to be statistically significantly higher in tissues with pterygium compared to the control group (p < 0.005) (p=0.005).