Investigation of the effect of Ferulic Acid on Gentamicin induced Nephrotoxicity in rats

Feruli cacid is a kind of phenolic compound that can be found in various fruits and vegetables. This study aims to investigate the effect of ferulic acid upon nefrotoxicity that is induced by gentamicin (GM). In this study, rats were separated into 4 groups such that each containing 8 randomly selected rats: Control group, Ferulic Acid (FA) group, Gentamicin (GM) group and Gentamicin+Ferulic Acid (GM+FA) group. Blood samples were collected after 24 hours following the 8-day trial period, and kidneys were taken out for histopathological evaluation. Serum urea, creatinine, uric acid and, LDH analyses were performed in auto analyser while MDA, AOPP, GSH, SOD, CAT, IL-6, TNF-α analyses were performed in ELISA, and kidney tissues were also examined histopathologically. Urea (p<0.001), creatinine (p<0.001), MDA (p<0.01), AOPP (p<0.001), IL-6 (p<0.01) and TNF-α (p<0.001) levels were found to be statistically and significantly lowered in GM+FA group when compared to GM group. As a result, ferulic acid has reduced the inflammation in nephrotoxicity induced by GM, causing decreased oxidative stress. In this study, anti inflammatory features of ferulic acid have come to the fore frontrather than the antioxidant features. We can say that ferulic acid reduces nefrotoxic damage and has protective properties for kidneys.