The relationship between serum apelin and some markers in Iraqi patients with atherosclerosis

To assess the severity and progression of coronary atherosclerosis, the study's goals were to measure the role of apelin levels in the progression of atherosclerosis patients and healthy volunteers and to look into any potential relationships between apelin and the parameters examined in patients with coronary atherosclerosis in the AL-Anbar Governorate of Iraq. In this study, Ninety participants defferent age from 40 to 73 years were included. There were two groups formed from them: The first group of patients was made up of 60 patients and 40 control group. Levels of apelin in the patient were significantly decreased than in the control. Serum concentrations of cTn-I, CK-MB, LDH, and AST were all significantly decreased in patients compared to healthy controls. Serum total cholesterol, LDL-C, TG levels were all significantly higher (p<0.001) and HDL-C level significantly lower (P<0.001) in patients compared with healthy controls. Glucose levels in the patients were 6.18 compared to 4.64 in controls (P<0.0001). HbA1c levels were 3.41 in patients and 1.15 % in controls (P<0.0001). Plasma apelin was strongly negatively associated with BMI, serum CK-MB, LDH, AST, cholesterol, TG, and LDL-C levels, and significantly positively correlated with HDL-C. These findings may indicate a prognostic function of apelin, at least in the development of atherosclerosis.