The comparison of Anti-CCP, MCP-1 and Anti-MCV between ankylosan spondylitis and normal population in patients with rheumatoid arthritis

35 rheumatoid arthritis,25 ankylosan spondylitis and 20 healthy volunteers were included in the study to compare Anti-CCP,Anti-MCV and MCP-1 levels with ankylosan spondylitis and with normal population.The groups that were included in the study were similar in terms of age and sex.(p>0,05)The Anti-CCP,Anti-MCV and MCP levels were studied in all the three groups.The durations of morning stiffness and illness of patients with rheumatoid arthritis were recorded.ESH,RF and CRP analysises were examined in the blood samples of the groups.Although it was determined in a high percentage in Anti-CCP rheumatoid arthritis patients,Anti-CCP in positive titre was not determined in Ankylosan spondylitis and in healthy volunteers.The sensivity of Anti-CCP for rheumatoid arthritis was calculated to be %48 and the specifity was %100.While determining Anti-MCV less often positive comparing with the Anti-CCP in rheumatoid arthritis patients, Anti-MCV positiveness was not determined in ankylosan spondylitis and in healthy volunteers.The sensivity of Anti-MCV for rheumatoid arthritis was calculated to be %25, and the specifity was %100.MCP-1 level was determined to be 382 pg/ml(SD:208,7) in rheumatoid arthritis group,284,5 pg/mL(SD:105.0) in ankylosan spondylitis group and 328,8 pg/mL(SD:104,8) in healthy volunteers.Among the groups no statistically meaningful difference was determined.(p:0.125)It was detected that Anti-CCP which is held as the 8. criterium of ACR by a lot of writers because it has a higher specifity than RF, can be determined significantly positive in patients with RF negative.We determined that Anti-CCP and RF,together,have a higher diagnostic potential than that they have individually. Having %25 sensitivity and %100 specifity on it's own,Anti-CCP, which has been stated,in a lot of study, to have as much diagnostic value as Anti-CCP , was determined to have %36 sensitivity and %92 specifity when used with RF,%55 sensitivity and %83 specifity when used with Anti-CCP.Morning stiffness duration which is one of the diagnostic criteria of rheumatoid arthritis was determined to be , on average 1,1 hour (SD:0.6), minimally 0,4 hour and maximumly 2,5 hours.In the rheumatoid arthritis group; positive,meaningful relations were determined between morning stiffness and Anti-CCP, durations of illness, CRP and sedimentation values.The positive relation between Anti-CCP , Anti-MCV and RF supports the fact that autoantibodies take a significant place in the etiopathogenesis of rheumatoid arthritis and makes us think that a patient who synthisizes an autoantibody is capable of synthesizing another autoantibody.The fact that there exist positive meaningful relations between ACP and illness activities makes us think that rheumatoid arthritis may progress more severely and in the patients who develop these autoantibodies and that they may develop erosive joint disease.Consequently, it becomes important that basic treatment should betimes be applied to these patients.In this study, we determining sensitivity of Anti-CCP and Anti-MCV less according to the literature, we determined the specifity high , similarly to the literature.As for MCP- 1 levels, we did not determine any meaningful difference between the patient with rheumatoid arthritis or ankylosan spondylitis and the healthy volunteers.Therefore, it is needed that studies on bigger scales should be realised regarding the utilisation of these tests in diagnosis and monitoring.