The effect of sugammadex on coagulation in pregnant rats

Introduction Sugammadex has been reported to affect coagulation parameters in some studies. However, the effects of sugammadex on coagulation in pregnant women have not been adequately studied. As it is defined to be cautious in the administration of sugammadex to pregnant women, this study was aimed to investigate the effect of sugammadex administration on routine coagulation tests and coagulation factors (FII, FV, FVII, FVIII, FIX, FX) in pregnant rats. Materials and Methods After the approval of the ethics committee (2019/06), a total of 24 female Winstar albino rats, 12 of which were between 19th-20th days of gestation, weighing 230-380 g, were randomly divided into 4 groups. Groups are determined as control group (group K, n=6), sugammadex group (group S, n=6), pregnant group (group G, n=6) and pregnant sugammadex group (group GS, n=6). 50 mg/kg ketamine and 10 mg/kg xylazine were applied intraperitoneally to all groups. 1 ml/kg SF was applied to groups K and G. Sugammadex was administered to groups S and GS at a dose of 16 mg/kg. Blood samples were taken 30 minutes after SF and sugammadex administration in all rats. PT(INR), aPTT, fibrinogen, Factor II, V, VII, VIII, IX, X were studied in plasma obtained from blood samples. After the procedure, the animals were sacrificed by cervical dislocation technique. The studied values were compared statistically between the groups. Results The mean weight of the rats in the pregnant group (group G and group GS) was found statistically significantly higher than non-pregnant groups (group K and group S). The mean PT and INR in the pregnant groups (group G and group GS) was found statistically significantly lower than non-pregnant groups (group K and group S).There was not determined statistically significant difference between the sugammadex and SF applied groups in all of the parameters we studied. Conclusions We believe that sugammadex administration has not effect on routine coagulation tests and coagulation factors (FII, FV, FVIII, FVIII, FIX, FX) in pregnant rats.