Evaluation of nesfatin-1, adropin, irisin and preptin values in patients with a history of recurrent pregnancy loss

Objectives: To investigate the association between irisin, nesfatin-1, adropin, and preptin levels with recurrent pregnancy loss (RPL). Material and methods: A prospective study conducted between January 2019 and July 2020 in Van Yuzuncu Yil University, Department of Obstetrics and Gynecology. One hundred women with a history of RPL and 104 women without such history were included for a total of 204 participants. Women with a history of RPL without a clear etiologic factor were included in the study. Irisin, nesfatin-1, adropin, and preptin levels were determined in venous blood samples. Data on gravida, parity, age, height, weight, body-mass index, and fasting blood glucose were collected from all participants. Results: A total of 204 women, 104 with a history of RPL and 100 without a history of RPL, were included in the study. At the time of venous sampling, 48.5% of participants (n: 99) were pregnant were as 51.5% (n: 105) of them were not. Irisin levels (median: 827.9 vs 832.7, P < 0.0001) levels were higher in pregnant women without a history of RPL compared to pregnant women with a history of RPL. Nesfatin1 (mean: -1044, 95% CI: -1150 – -938, P < 0.0001) and preptin (mean: -6.0, 95% CI: -6.19 – - 5.80, P < 0.0001) levels were higher in pregnant women without an history of RPL compared to pregnant women with an history of RPL. A repeat analysis for non-pregnant women at the time of venous sampling revealed similar results for irisin, adropin, nesfatin-1 ve preptin levels at a significance level of <0.0001. Conclusion : Irisin, nesfatin-1, preptin and adropin hormones have different effects on metabolism. It disrupts materno-fetal glucose homeostasis by directly or indirectly affecting insulin resistance (ID), It disrupts materno-fetal glucose homeostasis by directly or indirectly affecting insulin resistance (ID), by acting on molecular and immunological factors, induce villous thrombosis and thus impair placental blood flow or adversely affect endometrial receptivity, leading to implantation failure. Our study showed that the hormone levels of adropin and irisin were statistically significantly lower, while nesfatin-1 and preptin levels were higher in women with a history of RPL compared to control group. In order to reveal more clearly the relationship between nesfatin-1, irisin, adropin and preptin hormones with RPL, we need randomized controlled studies without the effect of confounding factors