Studies on the synthesis of tetracyclic 20-deethyl-4-demethyldacicarpidone and 20-deethyldemethyldacicarpidone

Since the first years of Alkaloids' discovery, studies have been carried out on the chemical properties and activities of alkaloids. In the field of determination of the structure and synthesis of indole alkaloids, significant advances have been made since the discovery of alkaloids. Strychnos type alkaloids are alkaloids obtained from the seeds of plants in the family Loganiacea found in South Asia. Since these alkaloids have a serious stimulant effect on the central nervous system, their role in medical therapy and toxicology is very important. Strychnos type alkaloids are mainly used in cancer and AIDS drugs. In addition, they are used as active ingredients in painkillers, drugs that prevent coagulation and lower blood pressure, in the treatment of asthma, cough and tuberculosis, drugs for nervous diseases and medical drugs. Alkaloids are found in plants, but since their rate in plants is very low, it is very important that they can be obtained synthetically. In this study, tert-butyl [2-methyl-1-(4-methyl-benzene-sulfonyl) by tetrachloro-1,4-benzoquinone (TCB)-mediated cyclization of the intermediate tetrahydracarbazole obtained from tert-butyl [2-methyl-1-] An efficient method for the synthesis of 20-deethyl-4demethyldacicarpidone and 20-deethyldacycarpidone from -1H-indol-3-yl]methyl carbonate is reported. 2-[9-(4-Methylbenzenesulfonyl)-2,3,4,9-tetrahydro-1H carbazol-2-yl] acetonitrile, which is the ABCD substructure of the Strychnos alkaloid family, was synthesized in a different way for the first time.