Study of factors affecting morbidity, mortality and graft survival in patients who were renal transplantation at Dicle University between 2012-2019

Purpose: Renal transplantation which are increasingly important in chronic renal failure (CRF) has been used more frequently all over the world thanks to the experiences in immunosuppressive therapy and surgical techniques. Post-transplant rejections negatively affect graft and patient survival. By this study, it has been aimed to investigate the factors that affect to rejection and survival. Method: In this study, the patients who had renal transplantation in Dicle University Hospital of Medicine Faculty between the dates of 1st January 2012 and 1st September 2019, were retrospectively investigated. It was researched on the mean of duration of patient and graft survival, and the characteristics of the patient, laboratory values, treatment principles at the time of diagnosis in this study. Results: In this study, the data collected from 72 patients who had renal transplantation and 68 donors was analysed. The mean age of the patients was 32,7±13,8 years. 31 of patients were female, 41 were male. 56 of the transplants were performed living donors and 12 from deceased donors. Hemodialysis was applied to 48 of the patients who underwent dialysis in the pre-transplant period, and peritoneal dialysis was applied to 8 of them. Preemptive transplantation was performed in 14 patients. There were 58 patients with a body mass index (BMI)≤30 and 14 patients with a body mass index (BMI) >30. 9 patients died. The mean of patient survival was 94±3,4 months. Graft loss occured in 15 patients. The mean of graft survival was 86±4,3 months. Acute rejection (AR) occured in 10 patients. Chronic allograft nephropathy (CAN) occured in 19 patients. CAN was found more frequently in patients with AR (p=0.017) and transplants from a female donor (p=0.047). In addition, graft loss was more common in patients with CAN (p=0.002). The dialysis duration was less than 12 months and the BMI of the recipient was below 30 had a positive effect on patient survival. Conclusion: Recipient obesity and long-term dialysis programs reduce patient survival. In addition, prevention of rejection has a positive effect on patient and graft survival. KEYWORDS: Renal transplantation, rejection, survival