A comparison of pulmonary function, functional capacity, muscle strength, physical activity, physical fitness and activities of daily living in cystic fibrosis patient's with and without abnormal glucose tolerance

Pulmonary function and exercise capacity were affected negatively from abnormal glucose tolerance (AGT) in children with cystic fibrosis (CF). However, there is a lack of information about how AGT affects muscle strength, physical activity, physical fitness, and activities of daily living (ADL) in CF. The study aimed to compare lung function, respiratory and peripheral muscle strength, functional capacity, physical activity, physical fitness, and ADL in CF patients with (AGT) and without (NGT) AGT. Lung function was recorded. Respiratory muscle strength was measured using a portable using a mouth pressure device. Quadriceps femoris muscle strength and handgrip strength were evaluated. Six-minute walk test (6MWT) and incremental shuttle walk test (ISWT) were performed. Bouchard Physical Activity Record and the Munich physical were applied. The ADL was determined using the Glittre ADL test. Lung function, respiratory muscle strength, physical activity, and physical fitness Glittre ADL test duration and ISWT distance were similar between the AGT and NGT groups (p>0.05). Quadriceps muscle strength, handgrip strength, anaerobic power, 6MWT distance were significantly lower in AGT than NGT (p<0.05). Resting and exercise heart rate, dyspnea, and perception of fatigue were significantly higher in the AGT group than those of the NGT group (p<0.05). In CF with AGT, compared to NGT, exercise capacity, peripheral muscle strength, and anaerobic power are affected negatively. Further study is needed to investigate the effects of exercise training in CF with AGT.