Investigating the anthelmintic effects of Rosmarinus officinalis L. and rosmarinic asid in mice naturally infected with Aspiculuris tetraptera

In this study, the anthelmintic effect of Rosmarinic asid, a component of Rosmarinus officinalis L. (Rosemary) plant and rosemary against Aspiculuris tetraptera in naturally infected mice was investigated. The faeces of 90 Balb/c mice, naturally infected with Asiculuris tetraptera, were determined by examining the feces by flotation method. Three doses of R. officinalis were examined. Infected mice were divided into 6 groups. Leaf extract of 1st group Rosemary plant 250 mg/kg, 2nd group R. officinalis 500 mg/kg, 3rd group R. officinalis 1000 mg/kg, 4th group Rosmarinic asid, 5th group albendazole, 6th group serum phiological. All groups were gavaged for 7 days. On the 8th day, all animals were euthanized and the number of parasites they contained was measured. Percentage of activity and p values were calculated. The effect values were % 89, 1399 of albendazole, % -8, 17 of Rosmarinic asid, % 25,44 of a 250 mg/kg Rosemary dose, % 46,54 of a 500 mg/kg Rosemary dose and % 7,16 of a 1000 mg/kg Rosemary dose. Albendazole has the highest effect value and Rosmarinic asid has the lowest effect value. P values were found to be significant in group 2 (p˂0,05), and insignificant in group 3, 4, 5, and 6 (p˃0,05).