Assessment of ATP-binding cassette transporter G5/G8 and lipid profile in patient with diabetic mellutis type 2

The present study intends to look into some of the reasons of diabetes by looking at polymorphisms in the ATP Binding Cassette( ABC) G5/G8 gene in Heet Hospital and the relationship between these polymorphisms and lipid and ABCG5/G8 levels Serum lipid profile levels were determined using colorimetric methods, while serum levels of both ABCG5/8 were determined using the ELISA technique. In addition, ABCG5 and ABCG8 gene polymorphisms Q604E (rs6720173) and D19H (rs11887534) They are mapped using a polymorphism in the length of the restriction reaction fragment and the polymeric chain reaction, respectively. The mean ± SD ages of the patients between (20-60) years. Fasting plasma levels of TC, TG, and LDL-C were significantly higher in the patient group than in the control group (P-value >0.05). Despite the fact that there was a statistically significant variation between groups in the distribution of ABCG 5/8 protein, no significant changes were observed (p 0.05). Finally, because of its high connection with the E allele and link with ABCG 5 protein levels, the polymorphism (Q604E) of the ABCG5 gene was designated a risk factor for DM illness. Keywords: Dm, Pcr –Replp, Lipid profıle, Snp, Elise