The association of matrix metalloproteinase-7, 10 with hepatitis C virus infections in chronic kidney diseases

The kidney is the most important excretory organ in humans, as it processes approximately 2,000 liters of blood daily, and when the kidneys are unable to remove wastes and are unable to maintaining the internal balance of mineral salts and water is kidney failure. Therefore, this study aimed to find non-invasive biomarkers to predict the diagnosis and monitor the progression of chronic kidney disease (CKD): including the level of matrix metallo proteinase MMP7 and MMP10 .Patients with CKD infected with hepatitis (HCV) were the focus of this study. 90 blood samples were collected, including 22 samples from individuals in good health (the control group): 22 samples from patients suffering from chronic kidney disease and hepatitis C infection, and 46 samples from the patients suffering from chronic kidney disease (samples were taken for Iraqi patients at Medical City Hospital after obtaining their verbal consent).The Sandwich ELISA technique was used in this study for blood samples taken to extract serum. It has been shown that the prevalence of chronic kidney disease (CKD) increases with age, especially from the age of 40 years and above. The results showed that the majority of patients suffering from chronic kidney disease (CKD) are male. This may be due to the activity of sex hormones or physical stress. The prevalence of chronic kidney disease (CKD) was found to be higher in rural areas compared to urban areas. It was noted that the majority of participants in the study had the ability to read and write. The research revealed that the majority of patients suffered from chronic kidney disease for two to three years. The significant number of patients with chronic kidney disease suffer from diabetes, as it is one of the main causes of kidney disorders. It was noted that MMP10 and MMP7 levels are higher in patients with CKD compared to patients with chronic kidney disease and hepatitis C virus. It was found that they have a positive relationship with degrees of renal fibrosis and a negative relationship with kidney function. In conclusion, elevated levels of MMP10 and MMP7 may be a marker for predicting tissue damage and worsening renal status in patients with CKD.