Serum soragel levels in children with asthma and relationship with oxidative stress

Asthma is an airway disease characterized by many inflammatory cells and mediators, characterized by complete or partial reversible obstruction of the respiratory tract. In this study, evaluation of sRAGE levels that a circulating oxidative stress biomarker, showing the status of in children aged 5-15 years diagnosed with asthma. In addition, to investigate the relationship of MDA, SOD and CAT levels, which are oxidative stress parameters, and serum total IgE, CRP and complete blood count levels with sRAGE marker and it is compared with the levels of healthy children. It is also to investigate the presence of oxidative stress in asthma and its relationship with sRAGE levels. Data regarding of 5-15 years old, 52 children with asthma, who applied to Namık Kemal University Research and Practice Hospital Pediatrics Clinic. The control group was made up of 33 healthy children. Asthma patients were divided into control levels within themselves according to disease activity good (n = 6), partial (n = 31) and uncontrolled (n = 15). Data regarding demographics and serum sRAGE, SOD, MDA, CAT, total IgE, CRP and hemogram levels were also obtained through file scanning. Serum sRAGE levels were significantly decreased compared to healthy controls (p = 0,000). In children with asthma, levels of lymphocyte, neutrophil and eosinophil levels and total IgE were significantly increased compared to healthy controls (p = 0.001, p = 0.002, p = 0.001, p = 0.000, respectively). CAT levels were significantly decreased compared to healthy controls (p = 0.002). In patients with severe asthma with increased disease activity, MDA levels were found to be significantly higher than the partially controlled patient group (p = 0.010). In the correlation analysis applied in the patient group with asthma, a positive correlation was found between SOD and WBC levels (p <0.05). As a result, sRAGE levels were found to be significantly correlated with oxidative stress parameters in asthmatic patients. It can be said that sRAGE has a protective role against oxidative stress effects. It shows that sRAGE can be used as a good marker in the diagnosis and follow-up of asthma.