Atorvastatin yüklü polimerik miseller üzerinde çalışmalar

In this scope, analytical method validation, determination of critical micel concentrations of copolymer and mixed copolymers, preparation of polymeric micelles, in vitro characterization on the micelles (particle size and distribution -PS-, polydispercity index -PDI-, zeta potential -ZP-, entrapment efficacy, aqueous solubility and dissolution rate, DSC, FT-IR, 1H-NMR), cell viability studies on MCF-7 and MDA-MB231 breast cancer cells, and stability studies were evaluated. Atorvastatin loaded polymeric micelles were prepared by thin film hydration method which is frequently used in the literature. Stability studies of micelles formulation were evaluated in 40oC stability cabin, 4oC refrigerator and 25oC dark environments.