Synthesis of benzofuran-based benzimidazole compounds andinvestigation of their antidiabetic effects

Within the scope of this thesis study, firstly 2-aryl-4,6-dimethyl and 2-aryl-4,6-dimethoxy benzofuran compounds were synthesized, and then these precursors were subjected to the Vilsmeier-Haack reaction and the aldehyde group was selectively added to the C3 and C7 positions. In the last part of the synthesis, benzofuran compounds with aldehyde functional group were reacted with different commercially available o-phenyl diamines to synthesize the target products, benzofuran-based benzimidazole compounds.The second part of the Project includes examination of in-vitro α-amylase and α-glucosidase enzyme inhibition of synthesized benzofuran-based benzimidazoles. Inhibition of these two enzymes is an effective therapeutic approach in reducing and controlling blood glucose levels in Type 2-Diabetes mellitus. The selection of enzymes was influenced by literature examples showing that different benzofuran derivatives are potent inhibitors of these two enzymes.The synthesized compounds were characterized by utilizing several methods including 1 H NMR, 13 C NMR, IR, and mass spectroscopy. When the appropriate crystals were obtained, the analysis of the synthesized compounds were elucidated using the X-ray crystallography method.