Biochemical comparative study for the role of vitamin B12 in type2 diabetic patients with dyslipidemia

One of the main risk factors for cardiovascular disease in people with diabetes mellitus is dyslipidemia. This study aimed to determine the role of vitamin B12 in diabetic patients with dyslipidemia. The study included 160 subjects divided into four groups: 40 of them were healthy, 40 had good diabetes control, 40 had fair diabetes control, while the last 40 were poor in diabetes control. All participants were tested for FBG, HbA1C, TG, CHOL, HDL and Vitamin B12. The parameters were statistically studied to find out the mean and the significant difference compared to the control group. The difference between the studied groups of patients was also studied, and the correlation coefficient was determined to know the correlation between the studied parameters. The levels of FBG, HbA1C, TG and CHOL increased in the fair-control group, and the level of HDL and vitamin B12 decreased. These levels were more dangerous in the poor control group, while the levels were similar or close to the control group in the good controlled group. The study achieved a clear positive correlation between HbA1C and TG (r=0.503), CHOL (r=0.459), while a negative correlation was observed between TG and HDL (r=-0.612), Vit. B12 (r='0.595) with a significant difference of (P<0.01). When compared with triglycerides, all other metrics clearly diverged