The association of serum creatinin/albumin ratio on admission with 1 year mortality in patients hospitalized due to decompansated heart failure

Aim: İn spite of developing treatments mortality is high in heart failure (HF). There are many parameters indicating mortality in HF. In our study, we aimed to investigate the relationship of serum creatinine/albumin ratio with the one-year mortality in patients with decompensated systolic HF. Methods: Between October 2014 and October 2015, 80 patients (37 women) admitted with acute systolic decompensated HF with left ventricular ejection fraction (EF) ≤ 40% were included in our study. After one year, the patients taken for study were divided into two groups: those who died due to all causes and those who survived. Findings: Out of 80 patients, taken for study, death occured in 31 (39%) of them after one year. The mean age was 69 ±14 years in the death group, 38.7% (n=12) women; in the living group the mean age was 66 ± 12 years, 51% were female (n = 25). The high ratio of serum creatinine/albumin and increase of urea and creatinine value and pretibial edema presence were statistically significantly higher in death group (p<0.01). Moreover, left ventricle EF, albumin value, number of lymphocyte, values of systolic and diastolic blood pressures were found to be significantly lower in terms of mortality in the death group of HF. Serum creatinine-albumin ratio was 0.68 ± 0.27 in the death group and 0,38 ± 0,18 in the surviving group, which was statistically significant (p<0.01). When the creatinine-albumin ratio was taken as 0.45, sensitivity and specificity were evaluated as 0.81 and 0.78 for one year mortality in HF patients. Conclusion: İncrease of creatinine and creatinine/albumin ratio and decrease of albumin, can be simple and useful markers which don't requrie additional cost to be used to predict one year all-cause mortality that's prognosis in patients with systolic decompensated HF. But there is no doubt that there is a need for randomized controlled trials involving a more comprehensive and a higher number of patients. Key words: Heart failure, creatinine/albumin ratio, albumin, creatinine, mortality