Comparison of pro-bnp levels and cardiac functions before and after iron therapy in children with congenital cyanotic cardiac disease and iron deficiency anemia

Aim: It is the comparison of NT-proBNP levels and cardiac functions after iron therapy in children with congenital cyanotic cardiac disease and iron deficiency anemia. Material and Method: Forty children between six months and 17 years old who were diagnosed with cyanotic congenital cardiac disease and iron deficiency anemia after referring to Çukurova University Faculty of Medicine Child Cardiology Department polyclinic between September 2015 and March 2016 were included in the study. Results for 26 patients were evaluated due to different reasons. Demographical data, total blood count, peripheral smear, reticulocyte, serum iron, total iron binding capacity, ferritin levels, transferrin saturations, NT-proBNP levels and Echo findings were evaluated in the first visit and third month controls of the patients. Findings: The study was completed with 26 patients and mean age was 57.7± 54.6 months. Laboratory values of the patients before and after iron therapy; hemoglobin, hematocrit, MCV, MCHC, iron, ferritin, transferrin saturation, oxygen saturation values increased statistically significantly after the theraphy. High RDW and NT-proNP levels decreased significantly in control results. Among ECHO findings, a borderline statistically significant difference was detected in the evaluation of left ventricular EF measurements among left ventricular systolic functions and right ventricular diastolic diameter measurements. A statistically significant difference was found in the comparison of right ventricular diastolic volume measurements. There was a significant difference in MPI measurements in left ventricule tissue doppler between 0 and 90th days. No significant difference was detected in other ECHO findings. Result: After iron therapy, recovery was detected in the cardiac functions of the children with cyanotic cardiac disease and NT-proBNP can be used in follow-up and evaluation of the treatment. Keywords: Cyanotic congenital cardiac disease, iron deficiency anemia, NT-proBNP, echocardiography