The neuroprotecti̇ve, anti-edema and anti-inflammatory effects of etanercept in the acute phase of experi̇mental head trauma

Objective: Traumatic brain injury, includes primary and secondary mechanisms of injury. Secondary damage, after hours or days, depending on the emerging and is composed of many complex pathophysiological mechanism. In the studies that is shown; to protect brain and spinal cord from sekonder injury, etanercept stops brain inflammatory response preventing leukocyte infiltration. In our study, rats were created severe closed diffuse brain injury, trauma after the creation of etanercept in the treatment of acute given anti-edema, anti-inflammatory and neuroprotective effect was investigated. Methods: This experimental animal study, the weights from 250 to 350 g adult male Sprague-Dawley rats ranging from 40 units were used. Subjects were ten rats in each group so that the control (K), trauma+serum physiological (T+SF); trauma with dexametazon (T+D); trauma with etanercept (T+E) groups. Etanercept and dexametazon studies, diluted with saline intraperitoneally. Medication after trauma 90 h of the rats were decapitated for examples histopathological and immünohistochemical examination. Results: We observed that, there is statistically significant differences between trauma+SF and trauma+dexametazon groups about edema and inflamatuar parameters (p=0,027), on the other hand we haven't seen significant differences about neuronal damage, astrositic damage ang glial apoptosis (p>0.05). For all parameters statistically meaningful differences have been retrieved between trauma+SF and trauma+etanercept groups (p=0,003). Groups of trauma+dexametazon and trauma+etanercept related to edema and inflamatuar parameters (p=0,032) and neurona damage, astrositic damage and glial apoptosis we obtained statistically significant differences. Conclusion: The results of our study; in the acute traumatic brain injury and traumatic brain injury secondary to trauma etanercept treatment in reducing inflammation, glial apoptsis, neuronal and astrocytic cell damage may be protective against the show. As a result of etanercept in the treatment of humans with acute traumatic brain injury was thought to be a useful option.