Experimental nonalcoholic steatohepatitis rats entodel functions of the liver and protective investigate the effects of Tribulus terrestrial

In the light of all these data, in the NASH table, occured depending on complex mechanisms and several aetiologic reasons, NO, ADMA, MMP and adhesion molecules are thought to be effective and play an important role on becoming chronic and on development of complication. In this study, we aimed to research the effects of Tribulus terrestris on NASH progress and on mechanisms and endothelium functions in the period of becoming chronic. In the study, 35 male Sprague-Dawley rats about weight of 200-220 g have been used. The rats were seperated to 5 groups, each of which has 7 rats. Group1; control group (8 weeks), Group2; NASH with fructose (8 weeks), Group3; given Tribulus terrestris during NASH progress (8 weeks), Group4; standard feding after NASH (14 weeks), Group5; given Tribulus terrestris after NASH progress (14 weeks). Rats were decapited after the study. Blood samples were taken and some biochemical parameters were studied. Liver, tissue and vessel samples taken from the rats were examined in the point of histopathology. The glucose, AST, ALT, total cholesterol, HDL, LDL, ICAM-1, VCAM-1, MMP-2, MMP-9, NO and ADMA levels were measured in the serum and the effects of Tribulus terrestris on these parameters were examined. After the formation of NASH, that we gave the Tribulus terrestris plant extract groups MMP-2, MMP-9 and ICAM-1 levels significantly different (p<0.05) were lower. During the formation of NASH, that we gave the Tribulus terrestris plant extract grops NO and ADMA levels significantly different (p<0.05) were lower. VCAM-1 levels significantly different between the groups weren't observed. We offer Tribulus terrestris plant extract groups, compared with the control group and created NASH group we give the plant extract to rats, which corrects liver function tests, ICAM-1, MMP-2, MMP-9, NO and ADMA levels reduce, also decreased histopathological confimation of fructose induced liver damage was observed. Consequently, Tribulus terrestris plant extract have a positive effect on the liver and endothelial function which can be useful to the etiopathogenesis of patients with NASH and it looks like a promising option has been concluded.