Determination of erythropoietin and cystatinc and some biochemical parameters in patients with chronic renal failure

This study has been designed to research in the role of anemia associated chronic kidney disease (CKD), and the vitamins D and C. The study has included 80 subjects with CKD, 40 male and 40 female of different stages of the disease and controlled with 40 un-diseased subjects of match ages. The results have shown a significant increase in the level of urea, creatinine, cystatin C, and ferritin in CKD patients compared to control. Additionally, the levels of erythropoietin, transferrin, hemoglobin, vitamin D, and vitamin C were reduced significantly in CKD patients compared to control. In CKD patients, cystatin C was correlated proportionally with creatinine and inversely with vitamin C. Also, vitamin C was correlated inversely with urea in CKD patients. Erythropoietin level has shown proportional correlation with ferritin and inverse correlation with hemoglobin in CKD patients. Furthermore, receiver operating characteristic (ROC) curve has indicated that cystatin C has very excellent sensitivity in the diagnosis of CKD. Vitamin D and vitamin C were shown excellent sensitivities in the diagnosis of CKD, while erythropoietin was shown fair sensitivity. In conclusion, anemia is frequently associated with CKD.