İnvestigations of antidepressant efficacy of trolox in depression model with immobilization stress in mice

İnvestigations of antidepressant efficacy of TROLOX in depression model with immobilization stress in mice. Student's Surname and Name: IŞIK, Ali Asım Adviser of Thesis : ERDİNÇ, Meral Professor Doctor Department : Pharmacology Aim:Depression is one of the major health problem in the world and its incidence is increasing day by day. Clasic antidepressants are not effective enough to treat depression and they have harmful side effects. Therefore, discocery of new antidepressants is very important for public health. The aim of this study was to investigate to antidepressant efficacy of trolox. In our study, therapeutical effects of trolox on pathways induced by stress in rats have been researched with the immobilization stress model designed for the experiment. Material and methods: With this aim, mice have been put into 4 groups; 1st group: control group (1 ml of sterile saline intraperitoneal (i.p.) once a day for 21 days), 2nd group: immobilization stress group (IM) (1 ml of sterile saline (i.p.) once a day for 21 days), 3rd group: Trolox (20 mg/kg (i.p.) once a day for 21 days), 4th group: IM + Trolox (20 mg/kg (i.p.) once a day for 21 days). After 21 days, depression levels were examined by behavioral tests and oxidation levels were examined by biochemical analyses. Results: The results of the behavioral tests showed that; depression was induced by immobilization model and trolox treatment improves depression. Data from biochemical analyzes showed that; the increase in malondialdehyde levels by immobilization, decreases with trolox treatment. Conclusion: It was understood that; a successful stress model can be established by immobilization model, and the observed disorders can be treated with trolox applications. Keywords: depression, antidepressants, antioxidants, anxiete, trolox