Investigation of changes in biochemical and hematological parameters in the rats drinking with different levels of arsenic water in yurtbasi

Arsenic (As) is a naturally occurring element that can be found in both organic and inorganic forms in soil and water. This study was planned to investigate the effects of drinking water (with arsenic) in Yurtbaşı (Elazığ) on the grounds that it has been curing various diseases for a long time. In this study, the waters with arsenic concentrations of 1000 ppb and 15,000 ppb were collected from two deep wells. The rats, 6-8 weeks of age, were divided into three groups of seven. The first group was fed with tap water, the second group was fed with 1000 ppb arsenic water and the third group was fed with 15.000ppb arsenic water for 6 weeks. At the end of the 6th week, animals were sacrificed by cervical decapitation without anesthesia to avoid animal stress.Plasma Glucose levels were decreased and Uric acid levels were significantly increased in the second and third group rats compared to the first group rats (p=0.04) .MCHC (p<0,001) and EO (%, #) values (p=0.034, p=0,038 respectively). were increased in the second and third groups. The target organ of arsenic is the liver. There was no significant change in liver values.This suggests that arsenic toxicity may become chronic after a longer period of time, or that arsenic is rapidly eliminated from the tissues. MCHC and eosinophil count, iron deficiency anemia and As toxicity in second and third group rats. Therefore, this may indicate premature loss of blood cells. Again, the presence of hyperuricemia in rats receiving high doses of As shows an inhibition of protein catabolism enzymes. Thus, high levels of As waters are consumed for a long time or used as basic drinking water in other organisms, leading to pathological disorders such as hypertension, metabolic syndrome, coronary heart disease, oxidative stress. In order to protect the toxic levels of arsenic, users of this type of drinking water are advised to consume more antioxidant molecules.