oligodendrogliom ve oligoastrositomlarda genetik risk faktörleri ve bu faktörlerin prognoz üzerine olan etkileri

Purpose: In this study, we aimed to investigate whether there is relationship between 1p and 19q deletions and prognosis in 15 cases with oligodendrogliomas which we did surgical treatment in our clinic between 2001 and 2010.Material and Method: 15 cases with oligodendroglial tumours that were operated in our clinic between 2001 and 2010 were determined by receiving faculty ethical committee and patient approvals. 1p and 19q deletions were investigated with fluoresence in situ hybridization method in the formaline - fixed paraffin sections. According to the deletion results, we devided these cases into 3 groups consisting of 5 as having both deletions(Group 1), having only 1p deletion (Group 2) and having neither of deletions (Group 3). And these groups are compared in terms of median ages during the diagnosis, median follow-up time and median progression free follow-up time and it was investigated whether there is relationship between these deletions and prognosis.Results: 1 of 15 cases whose pathology samples were studied with fluoresence in situ hybridization method was anaplastic oligoastrocytoma, 14 were oligodendroglioma grade 2 tumours. It was determined that in 5 of these 15 cases, both of 1p and 19q deletions exist . While only 1p deletion was determined in 5 cases, neither of these deletions was determined in 5 cases left. 2 of oligodendroglioma grade 2 tumours showed malign tranformation to anaplastic oligoastrocytomaThe median ages of cases during the diagnosis were 37,4 in Group 1, 41,8 in Group 2 and 34,2 in Group 3 and statistically no meaningful differences were found in terms of this parameter (p>0,05). For those having median follow-up time co-deletion was (Group 1) 28,6 months, for Group 2, 44,4 months and for Group 3, 63 months. Statistically no meaningful differences were found in terms of average follow-up time, either. Death resulting from tumour was seen in only one case (%6,7) and this case was in the group having neither deletions (Group 3). Therefore, no comparison could be done in terms of life time. While the rate of relapse for the group having co-deletion was % 0, it was determined as % 20 in the group having only 1p deletion and % 40 in the group having no deletion. Statistically, no meaningful differences were found when cases were evaluated in terms of rate of relapses, either (p>0,05). Median follow-up time was 38,2 months for Group 1, 48,6 months for Group 2 and 52,8 months for Group 3. median progression-free follow-up time was 38,2 months in the group having co-deletion since there was no fact showing progression, 23, 6 months in Group 2 and 40, 8 months in Group 3. Statistically, no meaningful differences were found among the groups for each of these parameters (p>0,05).Conclusion: In this study, due to the number of our cases was limited with 15, enough datas couldn?t be collected to get meaningful results statistically and statistical analiysises could be no more than definitions. In the light of these evaluations that are now routinely performed for these tumours all over the world, we carried out this study with the aim of being accepted as preliminary study, being able to form basis for future studies about molecular markers in oligodendroglial tumours and to light the way for some problems.Key words: Oligodendroglioma, molecular genetic changes, prognostic effects.