Gut hastalarında oksidatif stres düzeyi (malondialdehit), bazı antioksidan aktivitelerin (katalaz ve redükte glutatyon) ve ;MA (iskemi modifiye albumin) düzeyinin belirlenmesi

Gout is a may be and complex arthritis type that could affect anyone. It is characterized by the feeling of sudden and extreme bouts of pain, swelling and redness in the joints, particularly the joint at the base of the broad toe. Gout when forming uric acid crystals around the joint, causing inflammation and acute pain-(gout attack), uric acid crystals are formed in people whose uric acid level is high. The body produces uric acid as part of the purine process, a substance that is naturally present in the body and in certain types of food. Throughout this research, samples of blood serum from gout patients were obtained from the Van Yüzüncü Yıl University Hospital Orthopedics and Traumatology Clinic. This study was aimed at identifying the levels of lipid peroxidation malondialdehyde (MDA) and antioxidants such as reduced glutathione (GSH), catalase (CAT) and Ischemia Modified Albumin (IMA) in the blood serum of gouty patients. CAT and GSH activities were significantly decreased in the patient groups compared to the (healthy control group) (p<0.001). MDA levels were significantly higher in the group of patients relative to the balanced control group is (p<0.001). In conclusion, this study, oxidative stress may play an important-role in the development of gout disease.