Development of anti bacterial wound cover material from hydrogels

The aim of this study was to develop antibacterial dressing material from hydrogels. poly(Hydroxymethylacrylamide) p[NHMA] hydrogel was chosen to be used as wound dressing. hydrogels were synthesized in laboratory, and swelling equilibrium was calculated and the swelling was observed to stabilize around 400 minutes. Structural characterization of p[NHMA] hydrogels (FT-IR) was performed, and spectra in the wavelength range of 3830,94-560,30 cm-1 were obtained. Adsorption of (Ag+) silver cation with antibacterial effect on p[NHMA] hydrogel was tested. The Central Composite Design (MKD) model in the Response Surface Method (CYY) was used for optimization of initial Ag + concentration, pH, temperature and hydrogel content, which are the most important parameters affecting adsorption., The optimum values were determined as Co = 10.74 mg / L, pH = 3.15, temperature 13.03 ° C and hydrogel content as 0.12 g from the quadratic model obtained with MKD. The optimum yield under these conditions was found to be 91.6364%. After the optimization phase; the results were applied to the most known adsorption isotherm models. Adsorption equilibrium information was observed to be consistent with Langmuir isotherm model. In addition, thermodynamic parameters showed that the adsorption was exothermic.