The effect of insulin resistance on diastolic function of left ventricul

Our aim was o study he etological role of nsuln resistance n patents having eft ventricular diastolc dysfuncton whout any known cause. 28 patents (age between 18-50) having diastolc dysfuncton diagnosed by electrocardiagraphy at early age were ncluded n he study. Patents having clnical condions such as diabetes melus, pregnancy, eft ventricular concentric hypertrophy, coronary arter disease, severe valvular disease, cardiomyopathies, systolc dysfuncton and hypertension hat may contribute o relaxaton defect were excluded from the study. Dastolc unctons were measured using Doppler and ssue Doppler maging mode (TDI) of echocardiography equipment. In echocardiography, E and A velocies, sovolemc relaxaton me (IVRT), sovolemc contracton me (ICT, ejecton me (ET), deceleraton me of E wave (Edt) were measured. Moreover, ssue doppler and myocardial velocies were measured. 24 patents w h otaly normal echocardiographies were ncluded n case control group. HOMA nsuln resistance was calculated w h the formula: HOMA-IR= glukoz (mmol/l) X nsuln (ull/mL) / 225). HOMA-IR values of cases having and not having diastolc dysfuncton were compared. Thus, he efect of nsuln resistance on diastolc dysfuncton was evaluated. The average HOMA nsuln resistance value of 28 patents (age 45,64±5,47) having diastolc dysfuncton was ound as 2,26±1,37 whie HOMA nsuln resistance of 24 patents n control group was 1.87±0,85. Sudent's t-test revealed p:0.03. In patents having eft ventricular dysfuncton, HOMA nsuln resistance evels were ound o be signicanty higher compared o control group. This suggest hat nsuln resistance has an etological role n development of early onset diastolc dysfuncton.