Investigation of YKL-40 and oxidative stress in serum of patients with intracranial glial tumor

Purpose: As in all tumors, early diagnosis and treatment is very important in brain tumors too. We aimed to research by evaluating the relationship between intracranial glial tumor formation and stage and the biochemical markers YKL-40, Total antioxidant status (TAS), Total oxidant status (TOS), and Malondialdehyde (MDA), whether these markers can be brain glial tumor markers and have a significant role in the brain inflammation process. We aimed to investigate whether If meaningful results are obtained, it is planned to limit the levels of these molecules with pharmacological agents, and glial tumor regeneration and inflammatory process will be reduced, and beneficial results will be obtained in the rate of morbidity and mortality. Materıal And Methods: Between August 2021 and September 2023, 38 patients who underwent surgery for brain tumors in our clinic (Gaziantep University Faculty of Medicine, Department of Brain and Nerve Surgery) and whose histopathologies were recorded as low- or high-grade glial tumors, and 38 healthy control groups without chronic diseases were included in our study. . Before the surgical operation, venous blood was taken and serum levels of YKL-40, TAS, TOS and MDA were measured in the biochemistry laboratory using the ELISA method. It was determined that these molecules were degraded in the sera of low-grade glioma, high-grade glioma and healthy control samples. Results: Considering the laboratory results, TOS, YKL-40 and MDA measurements were found to be significantly higher in the patient group than in the control group. No significant difference was observed in TAS levels between the patient and healthy individual groups. On the other hand, YKL-40 levels were found to be statistically higher in high-grade glial tumors than in low-grade glial tumors, and no significant changes were observed in TAS, TOS and MDA levels between tumor groups. Conclusion: When the data are analyzed, we think that carcinogenesis is triggered as a result of the disruption of the oxidative balance and the increase in YKL-40 and MDA molecules may play a role in disrupting this balance and play a role in the etiology of glial tumors. We believe that by further expanding future studies, these molecule levels may provide guidance regarding the diagnosis and grade of glial tumors. We hope that the discovery of pharmacological agents that will reduce the levels of the same molecules will reduce the burden of these tumors, increase their surveillance, and provide guidance for new treatment methods. Key Words: YKL-40, TAS, TOS, MDA, glial Tumor, molecule