Investigation of serum levels of kisspeptin in intrauterin growth restriction cases

Appearence of birth weight under ten percentil or less for gestational age is the most commen description for İntrauterin growth restriction (IUGR). Feto-placental reasons keep an important place for IUGR etiology. The study shows that kisspeptins are secreted intensively by placenta and they have paraecrin and endocrin regulator function on trofoblasts and prevent trofoblast invasion.This study is performed to qualify serum levels of Kisspeptin-10 which is known that it has inhibition of trofoblast invasion at gestation period and to clear up its probable, potantional role on IUGR etiopathogenesis.30 healthy pregnants and 30 pregnants who have IUGR are joined to this study. There is no meaningful difference about gestational weeks between control group and study group. Demographic datas, laboratuar results and Doppler USG results are saved for all cases. Before birth, verous blood samples are taken from all cases. ELISA is worked on Kisspeptin-10. İndependent Samples T Test is used for assessment of results. Studied parameters relation with one another is assessed whereby Spearman correlation analysis. Less than 0,05 P values is admitted meaningful as statistical.Kisspeptin-10 levels of pregnants who have IUGR is found lower than healthy pregnants as statistical (p<0.05). Kisspeptin-10 serum levels are 3159,96±1345,74 pg/mL for study group and 4456,50 ±2989,32 pg/mL for control group.As a result, it?s thought that Kisspeptin-10 has a role on IUGR. Kisspeptin-10 can be used for predicting IUGR development beforetime, diagnosing and following IUGR.