The relationship between kallistatin protein in microvascular complications in Type 1 diabetes patients

Objective: Diabetes mellitus is a complex metabolic disorder characterized by a wide clinical spectrum, resulting from either an absolute or relative deficiency of insulin, or the development of insulin resistance in target tissues, leading to the involvement of multiple organ systems. The aim of our study is to investigate the kallistatin protein in patients within type 1 diabetes mellitus, comparing those with microvascular complications to a control group without such complications, and to elucidate the potential relationship of this protein with microvascular complications. MATERIALS AND METHODS: Between 01/08/2024- 31/06/2025 at Trakya University Endocrinology and Internal Medicine clinics; It was performed with a total of 118 cases, 59 in the patient group and 59 in the control group. In these patients, 24-hour urine proteinuria and 24-hour microalbuminuria, fundus examination, clinical neuropathy, and biochemical kallistatin protein measured during routine examinations, age, gender, height, weight, body mass index, duration of diabetes, prospective comparison was made between the patient group with microvascular complications in Type 1 diabetes mellitus patients and the control group without microvascular complications. P<0.05 was considered statistically significant. RESULTS: The mean age and duration of diabetes were significantly higher in the patients compared to the control group. However, no significant differences were.. Furthermore, the presence of microvascular complications (retinopathy, nephropathy, neuropathy) was associated with significant diffrences in kallistatin levels. Nevertheless, patients with two or more complications had significantly higher age and longer diabetes duration compared to those with fewer complications. CONCLUSİON: In our study, the relationship between kallistatin protein and microvascular complications in patients with type 1 diabetes mellitus was investigated. According to our findings, no statistically significant association was found between kallistatin levels and age, gender, height, weight, BMI, or the presence of microvascular complications."