Development of ultrasound-assisted controlled-release drug carrier systems for use in cancer therapy

In parallel with the latest positive developments in medical technology, ultrasound is used in different cancer diseases (eg, prostate, breast and developing cancer ablation), eye diseases (, uterine fibroid ablation, surgical tissue cutting and many other surgical operations and treatments. Also, drug delivery systems are used in drug delivery systems). It has also been found in the relevant literature that structures related to the ultrasound effect of target drugs can be used to control the release of the drug, as well as to increase (or control) the oxygen uptake that the target must provide at the site of application, and especially due to the limitations of drug carriers (e.g. endothelial cell alignment of blood vessels, for drug delivery). endothelial layers of targeted tissues, tightly ordered layers of epithelial cells, plasma membranes of cells and blood-brain barrier etc.) are accepted as the most basic goals and targets. Within the scope of this study presented; It has been possible to develop a cisplatin-loaded biopolymeric nanoparticular system made with bovine serum albumin (BSA), which provides controlled drug release with the effect of ultrasound on the cancer-curing active substance carrier system. Albumin nanoparticles were prepared by the desolvation method, optimized for users with their appearance dimensions, and then loaded with Cisplatin in different ways and designed to have the most appropriate drug and BSA properties. The prepared album has components with nanoparticles scanning electron microscopy, SEM for morphology, and DLS-based device for sizing and sizing distributions. The drug-loaded nanoparticles were then exposed to ultrasound at different amplitudes, and drug release profiles related to the ultrasound effect were obtained. Here, it was determined that the drug diffusion increased up to a certain ultrasound effect. The final experiments of the study were carried out by the Cytotoxicity-independent laboratory conducting ISO 10993-5 on drug-loaded nanoparticles, look at the effect of action on the toxic cell.