Long-term results in girls with central precocious puberty after leuprolide acetate treatment

Objective : Central precocious puberty (CPP) commonly refers to the development of pubertal sex characteristics as a consequence of the premature activation of the hypothalamic- pituitary-gonadal (HPG) axis before the age of 8 years in girls and 9 years in boys. This study's aim is to research the female patinet`s long term lenght gains who received leuprolide acetate with a diagnose of CPP. Material and Method : Between December 2002 and June 2013, a total of 70 female patients who has been monitored or given treatment after excluding acute or chronic illness because of central precocious puberty included in the study. From the files of the cases; anamnesis, physical examination, height of mother and father, midparenteral height (MPH) laboratory and radiological findings and weight, height and body mass index (BMI) before and after treatment recorded. Results: In 70 patients diagnosed as CPP and given leuprolide acetate treatment average for 21.73±8,45 months, predicted adult height (PAH) 157,7±7,4 cm, MPH 158,3±4,5 cm, final height found as 161,3±6,7 cm. In 3 patients final height standard deviation (SD) score was lower than -2SD. There was a statiscally significant positive correlation between final height and height age, MPH value, height on admission and after treatment (r=0,443, p<0,001, r=0,502, p<0,001, r=0,462, p<0,001 r=0,610, p<0,001 in order). The mean menstrual age after treatment found as 11,7±0,5 years. %97.1 of the patients have regular periods and %2.9 have irregular menstruel periods. Those 2 patients diagnosed as polycystic ovary syndrome (PCOS). There was statistically significant relation of BMI between before and after the treatment (p=0,328) Conclusion: It is shown that Leuprolide acetat therapy is efficient in suppressing HHG axis, preventing the advancement of pubertal findings, prolonging the menarch and preserving the final height. The treatment showed no adverse effects on increasing obesity and menstrual irregularity. Key Words: Precocious Puberty, Leuprolide Acetate, Final Height, Menstrual Regulation, Obesity