Comprasion of antinocyseptive effects of melatonin and agomelatine

ABSTRACT Objective: In the thesis, it is aimed that novel anti depressans which is MT1 and MT2 receptor agonist melatonin and which is MT1 and MT2 receptor agonist and at the same time 5-HT2c receptor antagonistic agomelatin will be comparised in terms of their antinociceptive effects. Method: In order to reach the aim, 64 male wistar rat which are 260-320 grams avarage weight, was used. Include control group, every group(n=8) has 8 rats. So as to evaluate antinociceptive effect, hot plate (50ºC) method was used. All drugs and vehicles are applied by intraperitonial way. The assesments of drug's effects were controlled after 30 minutes the drug was administered. Group 1: The control group, Group 2: Agomelatin 25 mg/kg (Ago25), Group 3: Agomelatin 35 mg/kg (Ago35), Group 4: Agomelatin 50 mg/kg (Ago50), Group 5: Agomelatin 35 mg/kg + Luzindole 10 mg/kg (Ago35+Luz10), Group 6: Melatonin 60 mg/kg (Mel60), Group 7: Melatonin 90 mg/kg (Mel90), Group 8: Melatonin 60 mg/kg+Sertralin 10 mg/kg (Mel60+Sert10). Results: Agomelatin, according to the control group, has reasonobly reached animal's reaction period in every 3 dosages(25,35,50 mg/kg). Nevertheless, Melatonin according to the control group, has reasonably reached animal's reaction period in 90mg/kg dosage. Melatonin's 60 mg/kg dosage has some reaction on animal but this change was not reasonable at all. When Sertralin 10 mg/kg was added to Melatonin 60 mg/kg dosage potansiliazed Melatonin's antinociceptive effect and the affermentioned effect has reached reasonable level according to the control group. Agomelatin's antinociceptive effect MT1 and MT2 receptor antagonist was reosonably controlled by using Luzindol. Conclusion: The outcomes of the research have figurred out that Agomelatin and Melatonin might have analgesic effects on rats nociceptive system. Agomelatin and Melatonin have a potantial to cure some pain syndromes. Melatonergic system and circadian circle might have effect on the therapy of the pain syndromes. Key Words: Melatonin, Agomelatin, antinociceptive effect, pain.