Neutrophil gelatinase associated lipocalin (NGAL) on acute gastrointestinal bleeding disorders of the kidney function that may occur EARLY impact of predictive and prognostic role)

Objective: To predict early stages of renal dysfunction and to determine the prognostic importance of NGAL in the patients who resort with gastrointestinal bleeding to Recep Tayyip Erdoğan Univercity Research and Training Hospital Emergency Clinic. Materials and Methods: 07.04.2016 - 08.07.2016 between this dates and prospectively and consecutively 50 patients who resorts to emergency service with bloody vomiting, bloody or black stools presenting with symptoms or after application who was diagnosis gastrointestinal bleeding. Patients or/and patients' relatives informed consent form (ICF) and after receiving approval were included in the study. Patients admitted to the emergency service, their blood group, blood count, biochemistry, coagulation profile, venous blood gases were studied; remaining serum was stored for NGAL. The same procedure was foll in the 24th hours at the clinic where they are. As a control group with no history of any disease than ever before, the positive physical examination findings undetected 50 healthy volunteers were included in the study. The values obtained were statistically compared by analysis of biochemical processes and then making another. Results: The patients beginning average value of NGAL is 94,27 ± 37,64 ng/mL and the control group average value of NGAL ise 83,67 ± 28.11 ng/mL, The difference between the two groups was not statistically significant (p>0.05). When the patients were evaluated in terms of their internal bleeding etiology of 0 and 24 hours value of NGAL, it was found to be statistically significant differences between groups (p <0.05). Conclusion: In the Emergency service patients resort with gastrointestinal bleeding NGAL may be useful for determining the etiology, the presence of bleeding and endoscopy and how many days hospitalized in the intensive care unit could be used as a biochemical parameters help in tracking decisions. Patients' NGAL value were not significantly high compared to healthy people. Gastrointestinal bleeding in patients as a predictor of mortality was determined that not enough information for NGAL. Bleeding in the gastrointestinal tract in patients with ARF it can be used as markers. In patients with diabetes, bleeding in the gastrointestinal tract can provide information about NGAL diabetic nephropathy. Keywords: GI Bleeding, ARF, NGAL