Histopathological and metabolic features comparison of non alcoholic fatty liver disease and patients with cryptogenic liver cirrhosis

İn this study we aimed to examine the features of non alcoholic fatty liver disease (NAFLD) and cryptogenic cirrhosis cases and to associate with each other. Also the patients groupped by their hystopatological features. The clinical and laboratory findings compared between the patient groups. We worked to explain the signs and which features starting cirrhotic progression.71 patients were examined which have followed up in Fırat Üniversity Medical Faculty Gastroenterology Clinic, 37 of these were have NAFLD and 34 of these were have cryptogenic liver cirrhosis.İn these patients hepatic function tests, hepatitis markers, autoantibodies, BMİ, waist circumference, lipid parameters, ferritin, fasting blood glucose, HbA1c, HOMA-İR and hepatic hystopatology commented.The mean age of cryptogenic cirrhosis patient group have found significantly higher (p=0,034). While the diabetic patient ratio was %27 in NAFLD group, the ratio was %50 in cryptogenic cirrhos patient group. (p=0,04). İn cryptogenic cirrhosis group prothrombin time, bilirubins and fasting blood glucose was significantly high. (in order p=0,0001, p=0,005, p=0,008). But albumin was determined as low. (p=0,0001). The insulin resistance measured by using HOMA-IR index. In NAFLD group, mean HOMA-IR index was found 2,48±1,81 (n=30) and in cryptogenic cirrhos group 7,2±9,04 (n=29). When the patient in NAFLD group compared with their grade and stage, mean ALT value was significantly high in grade 2-3 patients. There was no significantly difference in BMİ, waist circumference, lipid parameters and hypertansion prevalence commented. Histopathological examinations of the patients with cryptogenic cirrhosis are showed such features which can be also seen in nonalcholic steatohepatitis pericelluler fibrosis (n=10), periveinuler fibrosis (n=4), perisinuzoidal fibrosis (n=3), hepatosteatosis (n=9), lobular inflammation (n=8), hepatocelluler ballooning (n=13), wide lipogranuloma (n=3), giant mitochondria (n=2), mallory bodies (n=5) and glycogene nucleus (n=6).As a result NAFLD and cryptogenic cirrhosis is overlapping and in association with each other, such as metabolic syndrome criterias like diabetes mellitus, obesity, hypertension and hyperlipidemia. Some cases with cryptogenic cirrhosis have histopathological findings that can be seen in NAFLD even in the cirrhotic stage. İn this cirrhotic progression, DM and insulin resistance is seems to be the most important factor. Similar metabolic and histopathologic findings supports significant proportion of the patients with cryptogenic cirrhosis depends on the NAFLD.Key Words: Non Alcoholic Fatty Liver Disease, Cryptogenic Liver Cirrhosis