The prepation of new gel formulation for topical aplications of nsaids (non-steroidal anti-inflammatory drug): Investigation of potential controlled drug release

Novel gemini organogelators based on L-lysine, in which two L-lysine amino acides are linked by oxalyl amide from it's N6 amino groups through the amide bond, have been simply and effectively synthesized, and their organogelation abilities and thermal stabilities have been investigated. Bis(N2-Alkanoyl-N6-L-Lysyl-Ethyl Ester) Oxalyl Amides derivatives with different chain lenght alkanoyl groups at N2-Lysine moiety (4-6: N2-Alkanoyl=lauroyl, miristoyl, palmitoyl), as a novel LMWGs for pharmaceutical organic fluids have been explored to develop drug depot systems and illustrated for novel dermal and topical drug delivery vehicle for nonsteroidal drug molecule Naproxene. FAE's (Faty acid ethyl and isopropyl esters) which have different chain length, liquid paraffin, 1,2-propanediol, 1-decanol have been chosen as a biocompatible organic fluids which are used in cosmetic industry. Naproxene(Npx), acting as a model drug, was entrapped in the supramolecular organogels. The release behavior of Npx molecules in the supramolecular organogels was investigated by using UV–vis spectroscopy. The influence of concentration of the organogelator and drug, pH values of the accepting media, and nature of solvent (different FAE's, Liquid Paraffin, 1,2-Propanediol, 1-Decanol ) on the release behavior of Npx was investigated under static conditions. The results indicated that the release rate of Npx in the supramolecular organogels was effectively retarded with an increase of the organogelator concentration. Also, the release amount of Npx increased with increasing of the Npx content but this didn't the change release rate of Npx by increasing of it's amount. Furthermore, the release behavior of Npx was found to be different at various pH values in buffers as accepting media. The study of the release kinetics indicated that the release behavior of Npx was in accord with the Higuchi equation and the diffusion-controlled mechanism involved in the Fickian model. These observations indicate that bis(N2-Alkanoyl-N6-L-Lysyl-Ethyl Ester) Oxalyl Amides gels as delivery vehicle for nonsteroidal drug molecules and also show that the release profiles for such systems can be fine-tuned by the correct choice of gelator-solvent combination.