Relations between obstructive coronary artery disease and levels of blood 25OH-vitamin D, fetuin a, matrix gla protein and ADMA

The aim of the study is to compare 25OH-vitamin D, Matrix Gla Protein (MGP) , Fetuin-A , Asymmetric dimethylarginine status with obstructive coronary artery disease. In this study 80 cases were enrolled and were chosen from the cases who had coronary angioraphy process in our clinic . The study population consisted of group 1: normal coronary arteries cases (n=40) and group 2: obstructive coronary artery disease (? %70 occlusion of at least one coronary artery) cases (n=40) .The male cases were significanty more in group 2 (p<0,001) . The cases of group 1 were significantly younger than the cases of group 2 (p<0,001). Mean concentrations of MGP in group 2 (2082,79±329,75 pg/ml) were significantly higher than group 1 (1853,42±285,82 pg/ml) independent of gender status between the groups (p=0,001) . Also in diabetic cases, blood MGP levels were higher than non-diabetic cases (p<0,05) . After this finding, blood MGP levels for non-diabetic cases between group 1 and group 2 were studied and in group 2 blood MGP levels were significantly stil higher than group 1' s (p<0,05). This meant blood MGP levels were higher in group 2, independent from diabet status. Mean concentrations of Fetuin-A in group 2 (60,54±28,61 ng/ml) were significantly lower than group 1 (78,61±20,45ng/ml) independent of gender between the groups (p=0,002) . Mean concentrations of 25OH-vitamin D were deficient or insufficient in majority of the population (%85 of the population) and were not significantly different between group 1 (20,27±12,65 ng/ml) and group 2 (20,64±7,32 ng/ml) (p>0,05) . Also mean concentrations of ADMA were not significantly different between group 1 (0,099±0,053 umol/l ) and group 2 (0,089±0,051 umol/l) (p>0,05) . As a result of our study MGP and Fetuin-A were determined that these variables may be the markers of obstructive coronary artery disease. After this study we had a hope for approaching to diagnosis of obstructive coronary artery disease with simple blood tests but more studies with higher population are needed for comprehensive determination of these findings.