Effects of octyl-cyanoacrylate and fibrin adhesives on incisional wound healing

The aim of this study was to compare the effects of silk thread, octyl-cyanoacrylate and fibrin adhesives on incisional wound healing. Thirty-six 2-3 month old female Wistar albino rats (250-300 gr) were used in the study. The rats were randomly divided into 3 main groups (n=12). In this study, under general anesthesia, in the back of the rats, on the two sides of the lumbar vertebrae, 3 cm long longitudinal wounds were formed. The same procedure was performed in all rats and a total of 72 incisional skin wounds were obtained. The skin incisions in the rats in the first group were closed with a simple interrupted suture with 3/0 silk thread. The skin incisions in the second group of rats were closed with fibrin glue (FA) and the skin incisions in the third group were closed with octyl-cyanoacrylate (OCA). After the operation, macroscopically, complications such as inflammation of the wounds, infection formation and wound opening were evaluated and the scar formation was recorded. On the 3rd, 7th, 14th and 21st days after the operation, 3 rats from each group were euthanized and skin samples (6 pieces of each group) were taken from the wound areas including intact skin sections. Skin samples were divided into two parts, one part was used for histological examinations and the other part was used to measure wound tension resistance. The data obtained from the measurements of wound breaking strength showed that a significant increase in FA group only at day 7 (P <0.01). Histological findings showed that the best result in healing of incisional wounds was obtained in OCA treated group. As a result, OCA tissue glue can be used safely in closure of incisional skin wounds.