Investigation of D hypervitaminosis as A retrospective in pediatric patients

Lack of information or unnecessary use of vitamin D due to vitamin D insufficiency causes D hypervitaminosis. In this study, we aimed to retrospectively investigate the effects of D hypervitaminosis in the pediatric age group. Twenty patients who applied to Bursa Uludağ University Faculty of Medicine, Pediatric Outpatient Clinic between January 1, 2009 and November 15, 2019, with vitamin D elevation, were retrospectively analyzed. The patients' age at diagnosis, gender distribution, symptoms and signs such as weakness, fatigue, abdominal pain, nausea, vomiting, constipation, polyuria, polydipsia; electrolyte pathologies such as hypercalcemia, hypomagnesemia, hypercalciuria; parathormone, calciumxphosphorus, calcium/creatinine values; conditions such as arrhythmia, short QT in electrocardiography and presence of nephrolithiasis in urinary ultrasonography were investigated. Out of 20 cases, 55% (n = 11) constituting the study group were girls and 45% (n =9) were boys, and the mean age of the patients was 2.08 ± 1.69. It was found that 30% of the patients had weakness and fatigue, 35% had abdominal pain, 45% vomiting, 30% constipation, 25% polyuria-polydipsia. They were divided into two groups as vitamin D levels ≤150 ng/mL and >150 ng/mL. The vitamin D level of 6 patients was found to be ≤150 ng/mL, and the vitamin D level of 14 patients was found to be >150 ng/mL. No significant difference was found among the determined groups in terms of calcium, phosphorus, parathyroid hormone levels, hypercalciuria, and nephrocalcinosis in patients presenting with D hypervitaminosis. When the amount of dose taken and vitamin D level were compared, no significant correlation was found. When the amount of dose taken and the calcium level v were compared, the dose amount taken was found to be significantly higher in the group with calcium ≥10.80 mg/dl. The lack of an expected correlation between vitamin D levels and calcium and phosphorus levels may be associated with the low number of patients. In addition, the difference in serum and tissue levels of vitamin D and the difference in the time after high dose vitamin intake may explain the variability in calcium and phosphorus levels. These findings show that the expected hypercalcemia and hyperphosphatemia in D hypervitaminosis may not always be together. Keywods: Pediatric, D hypervitaminosis, hypercalcemia.