Petri Net-Based Quantitative Modeling and Validation of p16-mediated Signaling Pathway
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Özet (EN)
It has been a few decades since computer-based quantitative modeling methods are being applied to biological systems for enabling illustration and investigation of biological processes in a realistic way. One of the various modeling tools is Petri nets, which allow us to model pathways in biological sciences due to its extended definitions, such as hybrid functional Petri nets. In this dissertation, by using hybrid functional Petri nets, we propose the most detailed quantitative model for p16-mediated pathway, which is a critical pathway in tumor progression. Also, simulations were conducted to validate our model, and further to make some predictions regarding the quantitative behavior of the major components and complexes in this pathway. Keywords: hybrid functional Petri net, p16-mediated pathway, quantitative modeling, simulation
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Nimet İlke Akçay
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Nimet İlke Akçay (Doctorate thesis). Petri Net-Based Quantitative Modeling and Validation of p16-mediated Signaling Pathway, 2016, Eastern Mediterranean University, Department of Mathematics.
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